The Red Herring editorial team selected the 2012 Top 100 Americas in Santa Monica on May 23. They are the most innovative companies from a pool of hundreds from across the region. The Top 100 winners were judged on both quantitative and qualitative criteria, such as financial performance, CAGR, technology innovation, quality of management, execution of strategy, and integration into their respective industries.
| Company | Industry | Country |
| 10gen | Computers/Software | USA |
| Abine, Inc. | Security | USA |
| Accurence | Software | USA |
| Adap.tv | Internet & Services | USA |
| Adaptiva | Computers/Software | USA |
| Agilyx Corporation | CleanTech | USA |
| AlienVault Inc | Computers/Software | USA |
| Alpine Data Labs | Computers/Software | USA |
| Appcelerator | Mobile | USA |
| Artisan Infrastructure | Computers/Software | USA |
| AutoClaims Direct | Cloud Computing | USA |
| Azzimov | Social Network/Media | Canada |
| Backupify | Cloud Computing | USA |
| Beat the Traffic | Software | USA |
| BloomReach | Internet & Services | USA |
| Broadway Technology | Computers/Software | USA |
| ChaCha Search, Inc. | Computers/Software | USA |
| ClearSlide | Communications | USA |
| Clickatell | Telecommunications | USA |
| Cloudera, Inc. | Computers/Software | USA |
| Content Raven | Computers/Software | USA |
| CrowdFlower | Internet & Services | USA |
| CVISION Technologies | Software | USA |
| DealerSocket | Software | USA |
| Doximity | Social Network/Media | USA |
| Easy Solutions, Inc | Computers/Software | USA |
| Ecospan, LLC | CleanTech | USA |
| Ensim Corporation | Computers/Software | USA |
| Everyone Counts, Inc. | Cloud Computing | USA |
| Exinda, Inc. | Computers/Software | USA |
| Extole | Cloud Computing | USA |
| Fishbowl | Software | USA |
| ForeScout Technologies Inc. | Computers/Software | USA |
| Fusion Optix | CleanTech | USA |
| GENWI | Mobile | USA |
| Gigya | Social Network/Media | USA |
| Glaukos Corporation | Life Sciences | USA |
| Global Analytics | Internet & Services | USA |
| Global Village Concerns | Internet & Services | USA |
| GPS Insight | Software | USA |
| GumGum, Inc | Internet & Services | USA |
| HyperOffice | Computers/Software | USA |
| Infoaxe, Inc | Cloud Computing | USA |
| Innotas | Computers/Software | USA |
| InVisage | Semiconductor | USA |
| Jaspersoft | Computers/Software | USA |
| Kabbage, Inc. | Finance/Banking/Brokerage | USA |
| Liaison Technologies, Inc | Computers/Software | USA |
| LightSail Energy | Energy | USA |
| Madison Performance Group | Other | USA |
| Market Force | Other | USA |
| MedAvante, Inc. | HealthCare/Pharmaceuticals | USA |
| Memoir Systems | Semiconductor | USA |
| mobileiron | Computers/Software | USA |
| MyLife | Internet & Services | USA |
| NComputing | Computers/Software | USA |
| Nexsan | Computers/Software | USA |
| On Demand Therapeutics | HealthCare/Pharmaceuticals | USA |
| Ontraport | Cloud Computing | USA |
| Ooyala | Entertainment & Media | USA |
| PageFreezer Software, Inc. | Communications | Canada |
| Palantir Technologies | Software | USA |
| PaySimple | Computers/Software | USA |
| Ping Identity Corporation | Computers/Software | USA |
| PlayPhone | Mobile | USA |
| Puppet Labs | Computers/Software | USA |
| Pure Storage, Inc. | Hardware | USA |
| QuantiSense Inc. | Software | USA |
| Radisphere | HealthCare/Pharmaceuticals | USA |
| Redpine Signals | Semiconductor | USA |
| RedSeal Networks | Computers/Software | USA |
| Retailigence Corporation | Mobile | USA |
| Return Path | Computers/Software | USA |
| Revionics, Inc. | Cloud Computing | USA |
| Rimini Street | IT Consulting & Services | USA |
| RingRevenue | Software | USA |
| SalesPortal | Cloud Computing | USA |
| ScaleXtreme | Cloud Computing | USA |
| Scality | Software | USA |
| ScienceLogic Inc. | Software | USA |
| SendGrid | Computers/Software | USA |
| ServiceMesh, Inc. | Computers/Software | USA |
| Silver Tail Systems | Security | USA |
| Skyfire | Mobile | USA |
| SoftLayer Technologies | Internet & Services | USA |
| SolidFire | Computers/Software | USA |
| Solver, Inc. | Software | USA |
| Sonatype | Computers/Software | USA |
| Sumo Logic | Computers/Software | USA |
| Talenthouse Inc. | Entertainment & Media | USA |
| Tecplot, Inc. | Software | USA |
| Tegile Systems, Inc. | Computers/Software | USA |
| Trilliant | CleanTech | USA |
| Turn | Cloud Computing | USA |
| UpWind Solutions, Inc | Energy | USA |
| US Liner Company | Manufacturing | USA |
| UsTrendy | Entertainment & Media | USA |
| VigLink | Internet & Services | USA |
| Vindicia, Inc. | Computers/Software | USA |
| Wajam | Internet & Services | Canada |
| WideOrbit | Software | USA |
| Zaarly | Mobile | USA |
| Zencoder | Software | USA |
| Zenoss, Inc. | Software | USA |
| Zmags | Other | USA |